Vol. 36 (Suppl 1) 2015 Neuro endocrinology letters

Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro.

Stiborova M, Manhartova Z, Hodek P, Adam V, Kizek R, Eckschlager T, Frei E.

Journal Article 2015; 36(Suppl 1): 22-28 PubMed PMID: 26757112 Citation  Keywords:  Animals, Antineoplastic Agents:pharmacology, Cell Survival:drug effects, DNA Adducts:drug effects, Ellipticines:pharmacology, HL-60 Cells, Humans, In Vitro Techniques, Liver:drug effects, Micelles, Rats,.

OBJECTIVES: The improvements of cancer treatment are the major challenge in oncology research. Nanocarriers are one of the promising approaches to selectively target tumor cells, frequently leading to improve drug therapeutic index. Ellipticine is an anticancer agent that functions through multiple mechanisms. Here, the toxic effects of.....

Read abstract

The effects of heavy metal ions, phthalates and ochratoxin A on oxidation of carcinogenic aristolochic acid I causing Balkan endemic nephropathy.

Barta F, Levova K, Hodek P, Schmeiser H, Arlt V, Stiborova M.
Journal Article 2015; 36(Suppl 1): 13-21 PubMed PMID: 26757129 Citation  Keywords:  Animals, Aristolochic Acids:metabolism, Arsenic:pharmacology, Balkan Nephropathy, Cadmium:pharmacology, Carcinogens:metabolism, Chromatography, High Pressure Liquid, Ions, Lead:pharmacology, Metals, Heavy:pharmacology, Microsomes, Liver:metabolism, Ochrat.

Read abstract  Full text PDF

The effect of the fluoroquinolone norfloxacin on somatic indices and oxidative stress parameters in early stages of common carp (Cyprinus carpio L.).

Charvatova N, Zelinska G, Dobsikova R, Stancova V, Zivna D, Plhalova L, Blahova J, Sehonova P, Marsalek P, Bartoskova M, Prokes M, Piskorova I, Svobodova Z.
Journal Article 2015; 36(Suppl 1): 79-87 PubMed PMID: 26757128 Citation  Keywords:  Animals, Anti-Bacterial Agents:toxicity, Body Size:drug effects, Carps:embryology, Embryo, Nonmammalian:drug effects, Fluoroquinolones:toxicity, Glutathione Peroxidase:drug effects, Glutathione Reductase:drug effects, Glutathione Transferase:drug effects,.

Read abstract  Full text PDF

Role of dihydromyricetin in cytochrome P450-mediated metabolism and carcinogen activation.

Bostikova Z, Moserova M, Pavek P, Stiborova M, Hodek P.
Journal Article 2015; 36(Suppl 1): 46-52 PubMed PMID: 26757127 Citation  Keywords:  Animals, Carcinogens:metabolism, Cytochrome P-450 Enzyme System:drug effects, Flavonols:pharmacology, Inhibitory Concentration 50, Intestine, Small:drug effects, Liver:drug effects, Male, RNA, Messenger:drug effects, Rats, Rats, Wistar, Real-Time Polymera.

Read abstract  Full text PDF

Preparation and evaluation of carriers for detection of cholinesterase inhibitors.

Vetchý D, Pitschmann V, Vetchá M, Kašparovský T, Matějovský L.
Journal Article 2015; 36(Suppl 1): 95-99 PubMed PMID: 26757125 Citation  Keywords:  Acetylthiocholine:analogs & derivatives, Carboxymethylcellulose Sodium:analysis, Cellulose:analysis, Cholinesterase Inhibitors:metabolism, Dithionitrobenzoic Acid, Lactose:analysis, Materials Testing, Porosity, Povidone:analysis, Sulfhydryl Reagents,.

Read abstract  Full text PDF

Preparation and application of anti-peptide antibodies for detection of orphan cytochromes P450.

Hodek P, Hrdinova J, Macova I, Soucek P, Mrizova I, Burdova K, Kizek R, Hudecek J, Stiborova M.
Journal Article 2015; 36(Suppl 1): 38-45 PubMed PMID: 26757124 Citation  Keywords:  Animals, Antibodies:immunology, Antibody Formation, Blotting, Western, Cell Line, Tumor, Chickens, Cytochrome P-450 Enzyme System:immunology, Cytochrome P450 Family 2, Eggs, Electrophoresis, Gel, Two-Dimensional, Enzyme-Linked Immunosorbent Assay, Humans,.

Read abstract  Full text PDF

Oxidative stress indices and histopathological effects of the nonsteroidal antiinflammatory drug naproxen in adult zebrafish (Danio rerio).

Stancova V, Plhalova L, Tichy F, Doubkova V, Marsalek P, Hostovsky M, Svobodova Z.
Journal Article 2015; 36(Suppl 1): 73-78 PubMed PMID: 26757123 Citation  Keywords:  Animals, Anti-Inflammatory Agents, Non-Steroidal:pharmacology, Gills:drug effects, Glutathione Peroxidase:drug effects, Glutathione Transferase:drug effects, Kidney:drug effects, Lipid Peroxidation:drug effects, Liver:drug effects, Naproxen:pharmacology, .

Read abstract  Full text PDF

Neonatal withdrawal syndrome and perinatal asphyxia. How to manage the patient? Case Report.

Brucknerová I, Mach M, Dubovický M, Ujházy E.
Case Reports 2015; 36(Suppl 1): 53-56 PubMed PMID: 26757122 Citation  Keywords:  Asphyxia Neonatorum:complications, Disease Management, Humans, Infant, Newborn, Methadone:adverse effects, Morphine:therapeutic use, Narcotics:adverse effects, Neonatal Abstinence Syndrome:drug therapy, Opiate Substitution Treatment:adverse effects,.

Read abstract  Full text PDF

Mixture toxicity of microcystin-LR, paraoxon and bromadiolone in Xenopus laevis embryos.

Ondracek K, Bandouchova H, Hilscherova K, Kovacova V, Linhart P, Miksikova M, Mlcakova V, Osickova J, Pohanka M, Skochova H, Pikula J.
Journal Article 2015; 36(Suppl 1): 114-119 PubMed PMID: 26757121 Citation  Keywords:  4-Hydroxycoumarins:toxicity, Abnormalities, Drug-Induced, Animals, Anticoagulants:toxicity, Body Size:drug effects, Caspase 3:drug effects, Cholinesterase Inhibitors:toxicity, Embryo, Nonmammalian:drug effects, Enzyme Inhibitors:toxicity, Lipid Peroxidati.

Read abstract  Full text PDF

Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs.

Bureš J, Jun D, Hrabinová M, Tachecí I, Květina J, Pavlík M, Rejchrt S, Douda T, Kuneš M, Kuča K, Kopáčová M.
Journal Article 2015; 36(Suppl 1): 150-155 PubMed PMID: 26757120 Citation  Keywords:  Animals, Cholinesterase Inhibitors:pharmacology, Electromyography, Female, Muscle, Smooth:drug effects, Stomach:drug effects, Sus scrofa, Tacrine:analogs & derivatives,.

Read abstract  Full text PDF

Ferrous and ferric state of cytochromes P450 in intact Escherichia coli cells: a possible role of cytochrome P450-flavodoxin interactions.

Culka M, Milichovsky J, Jerabek P, Stiborova M, Martinek V.
Journal Article 2015; 36(Suppl 1): 29-37 PubMed PMID: 26757119 Citation  Keywords:  Aryl Hydrocarbon Hydroxylases:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochrome P-450 CYP1A2:metabolism, Cytochrome P-450 CYP2A6:metabolism, Cytochrome P-450 CYP2B6:metabolism, Cytochrome P-450 CYP2C8:metabolism, Cytochrome P-450 CYP2C9:metabolis.

Read abstract  Full text PDF

Effects of acute exposure to deltamethrin and recovery time on common carp (Cyprinus carpio L.).

Stara A, Zuskova E, Machova J, Priborsky J, Velisek J.
Journal Article 2015; 36(Suppl 1): 133-140 PubMed PMID: 26757116 Citation  Keywords:  Animals, Carps:blood, Catalase:drug effects, Gills:drug effects, Glutathione Reductase:drug effects, Hematocrit, Hemoglobins:drug effects, Insecticides:toxicity, Kidney:drug effects, Liver:drug effects, Nitriles:toxicity, Oxidative Stress:drug effects, Py.

Read abstract  Full text PDF

Effect of polymeric nanoparticle poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) on in vitro luteinizing hormone release from anterior pituitary cells of infantile and adult female rats.

Scsukova S, Mlynarcikova A, Kiss A, Rollerova E.
Journal Article 2015; 36(Suppl 1): 88-94 PubMed PMID: 26757115 Citation  Keywords:  Animals, Animals, Newborn, Diethylstilbestrol:toxicity, Estrogens, Non-Steroidal:toxicity, Female, Gonadotrophs:drug effects, Gonadotropin-Releasing Hormone:pharmacology, In Vitro Techniques, Lactates:toxicity, Luteinizing Hormone:drug effects, Nanopartic.

Read abstract  Full text PDF

Effect of arsenic and cyanobacterial co-exposure on pathological, haematological and immunological parameters of rainbow trout (Oncorhynchus mykiss).

Palikova M, Papezikova I, Kopp R, Mares J, Markova Z, Navratil S, Adamovsky O, Kohoutek J, Navratil L, Blaha L.
Journal Article 2015; 36(Suppl 1): 57-63 PubMed PMID: 26757114 Citation  Keywords:  Animals, Arsenic:pharmacology, Bacterial Infections:blood, Carcinogens:pharmacology, Cyanobacteria, Erythrocyte Indices:drug effects, Iron:blood, Leukocyte Count, Microcystins:pharmacology, Microcystis, Neutrophils:drug effects, Oncorhynchus mykiss:blood,.

Read abstract  Full text PDF

Degradation rate of praziquantel and fenbendazole in rainbow trout following oral administration.

Soukupova-Markova Z, Doubkova V, Marsalek P, Svobodova Z, Papezikova I, Lang S, Navratil S, Palikova M.
Journal Article 2015; 36(Suppl 1): 64-67 PubMed PMID: 26757113 Citation  Keywords:  Administration, Oral, Animals, Anthelmintics:pharmacokinetics, Antinematodal Agents:pharmacokinetics, Chromatography, Liquid, Fenbendazole:pharmacokinetics, Oncorhynchus mykiss:metabolism, Praziquantel:pharmacokinetics,.

Read abstract  Full text PDF

Concentration of heavy and toxic metals in fish and sediments from the Morava river basin, Czech Republic.

Dvořák P, Andreji J, Mráz J, Líšková Z.
Journal Article 2015; 36(Suppl 1): 126-132 PubMed PMID: 26757111 Citation  Keywords:  Animals, Cadmium:analysis, Chromium:analysis, Czech Republic, Fishes, Geologic Sediments:chemistry, Lead:analysis, Mercury:analysis, Metals, Heavy:analysis, Muscle, Skeletal:chemistry, Poisoning, Rivers, Water Pollutants, Chemical:analysis, Zinc:analysis,.

Read abstract  Full text PDF

Comparison of the effect of four anaesthetics on haematological profiles, oxidative stress and antioxidant enzymes in barbel (Barbus barbus).

Priborsky J, Stara A, Rezabek J, Zuskova E, Lepic P, Velisek J.
Comparative Study 2015; 36(Suppl 1): 141-146 PubMed PMID: 26757110 Citation  Keywords:  Aminobenzoates:pharmacology, Anesthetics:pharmacology, Animals, Clove Oil:pharmacology, Cyprinidae, Ethylene Glycols:pharmacology, Etomidate:pharmacology, Gills:drug effects, Glutathione Reductase:drug effects, Liver:drug effects, Muscle, Skeletal:drug ef.

Read abstract  Full text PDF

A study on 17alpha-ethinylestradiol metabolism in rat and Pleurotus ostreatus.

Borek-Dohalska L, Valaskova P, Kubickova B, Sulc M, Kresinova Z, Cajthaml T, Stiborova M.
Journal Article 2015; 36(Suppl 1): 5-12 PubMed PMID: 26757108 Citation  Keywords:  Animals, Aryl Hydrocarbon Hydroxylases:metabolism, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP1A1:metabolism, Cytochrome P-450 CYP3A:metabolism, Cytochrome P-450 Enzyme System:metabolism, Cytochrome P450 Family 2, Ethinyl Estradiol:metaboli.

Read abstract  Full text PDF