Bureš J, Jun D, Hrabinová M, Tachecí I, Květina J, Pavlík M, Rejchrt S, Douda T, Kuneš M, Kuča K, Kopáčová M.
Journal Article 2015; 36(Suppl 1): 150-155 PubMed PMID: 26757120 Keywords: Animals, Cholinesterase Inhibitors:pharmacology, Electromyography, Female, Muscle, Smooth:drug effects, Stomach:drug effects, Sus scrofa, Tacrine:analogs & derivatives,. CitationOBJECTIVES: Tacrine was the first acetylcholinesterase inhibitor approved for therapy of Alzheimer's disease. It has currently been withdr.....
Bureš J, Jun D, Hrabinová M, Tachecí I, Květina J, Pavlík M, Rejchrt S, Douda T, Kuneš M, Kuča K, Kopáčová M. Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 1): 150-155
Kuneš M, Květina J, Bureš J, Karasová J, Pavlík M, Tachecí I, Musílek K, Kuca K.
Journal Article 2014; 35(Suppl 2): 191-196 PubMed PMID: 25638385 Keywords: Animals, Cholinesterase Reactivators:administration & dosage, Female, Oximes:administration & dosage, Pyridinium Compounds:administration & dosage, Sus scrofa:blood, Tissue Distribution,. CitationOBJECTIVES: Oxime HI-6 DMS (dimethanesulfonate) is an asymmetric bis-pyridinium aldoxime and essential acetylcholinesterase (AChE.....
Kuneš M, Květina J, Bureš J, Karasová J, Pavlík M, Tachecí I, Musílek K, Kuca K. HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs. Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 2): 191-196
Bures J, Kvetina J, Pavlik M, Kunes M, Kopacova M, Rejchrt S, Jun D, Hrabinova M, Kuca K, Tachecí I.
Journal Article 2013; 34(Suppl 2): 79-83 PubMed PMID: 24362097 Keywords: Animals, Cholinesterase Reactivators:administration & dosage, Electromyography, Female, Heart Rate:drug effects, Injections, Intramuscular, Models, Animal, Oximes:administration & dosage, Paraoxon:administration & dosage, Pyridinium Compounds:administrati. CitationOBJECTIVES: Organophosphorus compounds represent nerve agents, pesticides and several industrial compounds. Treatment after exposure to or.....
Bures J, Kvetina J, Pavlik M, Kunes M, Kopacova M, Rejchrt S, Jun D, Hrabinova M, Kuca K, Tachecí I. Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 79-83
Zdarova Karasova J, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tachecí I, Kuca K.
Comparative Study 2013; 34(Suppl 2): 74-78 PubMed PMID: 24362096 Keywords: Absorption, Animals, Biological Availability, Chlorides:administration & dosage, Cholinesterase Reactivators:administration & dosage, Female, Injections, Intramuscular, Injections, Intravenous, Oximes:administration & dosage, Pyridinium Compounds:administ. CitationOBJECTIVES: Oxime HI-6 is an acetylcholinesterase reactivator therapeutically efficient against nerve agents. Because of their physico-che.....
Zdarova Karasova J, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tachecí I, Kuca K. Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 74-78
Hroudová J, Fisar Z, Korábečný J, Kuča K.
Journal Article 2011; 32(3): 259-263 PubMed PMID: 21712782 Keywords: Animals, Brain Chemistry:drug effects, Cholinesterase Inhibitors:pharmacology, Cholinesterase Reactivators:pharmacology, Electron Transport:drug effects, Electron Transport Chain Complex Proteins:antagonists & inhibitors, Electron Transport Complex I:meta. CitationOBJECTIVES: Inhibition of the enzyme acetylcholinesterase (AChE) is the main mechanism both of therapeutic action of drugs for the treatme.....
Hroudová J, Fisar Z, Korábečný J, Kuča K. In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain. Neuro Endocrinol Lett. 2011 Jan; 32(3): 259-263
Pohanka M, Pejchal J, Horackova S, Kuca K, Bandouchova H, Damkova V, Pikula J.
Evaluation Studies 2010; 31(Suppl 2): 62-68 PubMed PMID: 21187825 Keywords: Animals, Antidotes:pharmacology, Antioxidants:pharmacology, Glutathione Reductase:metabolism, Liver:drug effects, Male, Models, Animal, Oxidative Stress:drug effects, Oximes:pharmacology, Pyridinium Compounds:pharmacology, Radiation, Ionizing, Rats, Rats,. CitationOBJECTIVES: HI-6 is an antidotum suitable for treatment of intoxication by nerve agents. The recent investigation appointed its modulation.....
Pohanka M, Pejchal J, Horackova S, Kuca K, Bandouchova H, Damkova V, Pikula J. Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model. Neuro Endocrinol Lett. 2010 Jan; 31(Suppl 2): 62-68