Articles by author - Tomas Cajthaml

Exposure of rats to exogenous endocrine disruptors 17alpha-ethinylestradiol and benzo(a)pyrene and an estrogenic hormone estradiol induces expression of cytochromes P450 involved in their metabolism.

Borek-Dohalska L, Klusonova Z, Holecova J, Martinkova M, Barta F, Dracinska H, Cajthaml T, Stiborova M.

Journal Article 2016; 37(Suppl 1): 84-94 PubMed PMID: 28263535  Keywords:  Animals, Benzo(a)pyrene:pharmacology, Cytochrome P-450 Enzyme System:metabolism, Endocrine Disruptors:pharmacology, Estradiol:pharmacology, Estrogens:pharmacology, Ethinyl Estradiol:pharmacology, Male, Microsomes, Liver:metabolism, Rats, Rats, Wistar,.    Citation

OBJECTIVES: The term "endocrine disruptor" (ED) is used for compounds that mimic or antagonize the effects of endogenous hormones. Synthet.....

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A study on 17alpha-ethinylestradiol metabolism in rat and Pleurotus ostreatus.

Borek-Dohalska L, Valaskova P, Kubickova B, Sulc M, Kresinova Z, Cajthaml T, Stiborova M.

Journal Article 2015; 36(Suppl 1): 5-12 PubMed PMID: 26757108  Keywords:  Animals, Aryl Hydrocarbon Hydroxylases:metabolism, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP1A1:metabolism, Cytochrome P-450 CYP3A:metabolism, Cytochrome P-450 Enzyme System:metabolism, Cytochrome P450 Family 2, Ethinyl Estradiol:metaboli.    Citation

OBJECTIVES: 17α-Ethinylestradiol (EE2) is an endocrine disruptor that is an ingredient of oral contraceptives. Here, EE2 metabolism catal.....

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