Vol. 29 (5) 2008 Neuro endocrinology letters

Biliary 1-hydroxypyrene as a biomarker of exposure to polycyclic aromatic hydrocarbons in fish.

OBJECTIVES: The aim of this study was the assessment of the Svitava and Svratka rivers contamination by polycyclic aromatic hydrocarbons (PAH) using 1-hydroxypyrene (1-OHP) concentrations in fish bile as a biomarker.

DESIGN: Levels of 1-OHP were determined by reverse phase HPLC with fluorescence detection. For va.....