Vol. 29 (5) 2008 Neuro endocrinology letters

Interspecies comparison of the glucuronidation processes in the man, monkey, pig, dog and rat.

OBJECTIVES: The study of interspecies differences in glucuronidation processes in the man, monkey, pig, dog and rat using liver microsomal fraction. The study is focused on determination of the enzyme activity of UGT1A6 (having also a toxicological importance) in microsomes of different species.

METHODS: For dete.....