Bureš J, Jun D, Hrabinová M, Tachecí I, Květina J, Pavlík M, Rejchrt S, Douda T, Kuneš M, Kuča K, Kopáčová M.
Journal Article 2015; 36(Suppl 1): 150-155 PubMed PMID: 26757120 Keywords: Animals, Cholinesterase Inhibitors:pharmacology, Electromyography, Female, Muscle, Smooth:drug effects, Stomach:drug effects, Sus scrofa, Tacrine:analogs & derivatives,. CitationOBJECTIVES: Tacrine was the first acetylcholinesterase inhibitor approved for therapy of Alzheimer's disease. It has currently been withdr.....
Bureš J, Jun D, Hrabinová M, Tachecí I, Květina J, Pavlík M, Rejchrt S, Douda T, Kuneš M, Kuča K, Kopáčová M. Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 1): 150-155
Bures J, Kvetina J, Pavlik M, Kunes M, Kopacova M, Rejchrt S, Jun D, Hrabinova M, Kuca K, Tachecí I.
Journal Article 2013; 34(Suppl 2): 79-83 PubMed PMID: 24362097 Keywords: Animals, Cholinesterase Reactivators:administration & dosage, Electromyography, Female, Heart Rate:drug effects, Injections, Intramuscular, Models, Animal, Oximes:administration & dosage, Paraoxon:administration & dosage, Pyridinium Compounds:administrati. CitationOBJECTIVES: Organophosphorus compounds represent nerve agents, pesticides and several industrial compounds. Treatment after exposure to or.....
Bures J, Kvetina J, Pavlik M, Kunes M, Kopacova M, Rejchrt S, Jun D, Hrabinova M, Kuca K, Tachecí I. Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 79-83
Zdarova Karasova J, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tachecí I, Kuca K.
Comparative Study 2013; 34(Suppl 2): 74-78 PubMed PMID: 24362096 Keywords: Absorption, Animals, Biological Availability, Chlorides:administration & dosage, Cholinesterase Reactivators:administration & dosage, Female, Injections, Intramuscular, Injections, Intravenous, Oximes:administration & dosage, Pyridinium Compounds:administ. CitationOBJECTIVES: Oxime HI-6 is an acetylcholinesterase reactivator therapeutically efficient against nerve agents. Because of their physico-che.....
Zdarova Karasova J, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tachecí I, Kuca K. Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 74-78
Soukup O, Pohanka M, Tobin G, Jun D, Fusek J, Musilek K, Marek J, Kassa J, Kuca K.
Journal Article 2008; 29(5): 759-762 PubMed PMID: 18987577 Keywords: Acetylcholinesterase:metabolism, Animals, Biosensing Techniques, Butyrylcholinesterase:metabolism, Cholinesterase Inhibitors:pharmacology, Methacholine Chloride:pharmacology, Muscarinic Agonists:pharmacology, Oximes, Parasympathetic Nervous System:drug ef. CitationOBJECTIVES: The current standard treatment of organophosphate poisoning consists of an administration of anticholinergic drugs and choline.....
Soukup O, Pohanka M, Tobin G, Jun D, Fusek J, Musilek K, Marek J, Kassa J, Kuca K. The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder. Neuro Endocrinol Lett. 2008 Oct; 29(5): 759-762