Articles by author - Ioannis Nicolaou

The effect of aldose reductase inhibition by JMC-2004 on hyperglycemia-induced endothelial dysfunction.

Papezikova I, Pekarova M, Chatzopoulou M, Nicolaou I, Demopoulos V, Kubala L, Lojek A.

Journal Article 2008; 29(5): 775-778 PubMed PMID: 18987578  Keywords:  Aldehyde Reductase:antagonists & inhibitors, Animals, Blotting, Western, Calcimycin:pharmacology, Cattle, Cell Line, Electrochemistry, Endothelial Cells:drug effects, Endothelium, Vascular:drug effects, Enzyme Inhibitors:pharmacology, Glucose:pharmacology.    Citation

OBJECTIVES: An increased glucose utilization by aldose reductase (ALR-2) has been implicated in the pathogenesis of diabetic vascular comp.....

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