Articles by author - Karel Naiman

Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole.

Naiman K, Frei E, Stiborova M.

Journal Article 2010; 31(Suppl 2): 36-45 PubMed PMID: 21187827  Keywords:  Aniline Compounds:metabolism, Animals, Anisoles:metabolism, Aryl Hydrocarbon Hydroxylases:physiology, Carcinogens:metabolism, Cytochrome P-450 CYP2E1:physiology, Cytochrome P-450 Enzyme System:physiology, Environmental Pollutants:metabolism, Hydroxylamine.    Citation

OBJECTIVES: N-(2-methoxyphenyl)hydroxylamine is a human metabolite of two industrial and environmental pollutants and bladder carcinogens .....

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Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA.

Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M.

Journal Article 2008; 29(5): 728-732 PubMed PMID: 18987592  Keywords:  Acetyl Coenzyme A:metabolism, Arylamine N-Acetyltransferase:metabolism, Arylsulfotransferase:metabolism, Autoradiography, Catalysis, DNA:chemistry, DNA Adducts:chemistry, Deoxyguanosine:chemistry, Ellipticines:chemistry, Hydrogen-Ion Concentration, Indica.    Citation

OBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of its action. Recently, we have found that 13-hyd.....

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