Vol. 29 (5) 2008 Neuro endocrinology letters

Prenatal developmental toxicity study of the pyridoindole antioxidant SMe1EC2 in rats.

OBJECTIVE: The 2-ethoxycarbonyl-8-methoxy-2,3,4,4a,5,9b-hexahydro-1H-pyrido-[4,3b] indolinium chloride (SMe1EC2) is a prospective antioxidant and neuroprotectant drug. The aim of the study was to evaluate the effect of SMe1EC2 on embryofetal development of rats.

METHODS: The substance tested was administered oral.....