The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.

Maes M, Mihaylova I, Ruyter M, Kubera M, Bosmans E.

Journal Article 2007; 28(6): 826-831 PubMed PMID: 18063923 Keywords: Adult, Anti-Inflammatory Agents:immunology, Cytokines:immunology, Depressive Disorder:metabolism, Female, Gene Expression Regulation:immunology, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase:immunology, Inflammation:metabolism, Interferon-gamma:immunology,.

: Immune activation is accompanied by induction of indoleamine (2,3)-dioxygenase (IDO), an enzyme which degrades tryptophan, a phenomenon which plays a role in the pathophysiology of major depression and post-natal depression and anxiety states. TRYCATs - tryptophan catabolites along the IDO pathway - such as kynurenine, kynurenic acid,.....

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Vol. 28 (6) 2007 Neuro endocrinology letters

The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.

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