Vol. 32 (4) 2011 Neuro endocrinology letters

Glucocorticoid receptor polymorphism is associated with lithium response in bipolar patients.

OBJECTIVES: Glucocorticoid receptor has been considered in the pathogenesis of bipolar disorder as it is an important regulator of the circadian rhythm and HPA negative feedback. As glucocorticoid receptor may be possibly related to lithium action we aimed to investigate variation in the GR gene in association with response to lithium t.....