Vol. 32 (4) 2011 Neuro endocrinology letters

Ephedrine enhances the antinociceptive effect of dexmedetomidine in mice.

OBJECTIVES: Dexmedetomidine, a highly selective alpha-2-adrenoceptor agonist, was recently introduced into clinical practice for its sedative and analgesic properties. The purpose of this study was to evaluate whether the psychostimulant drug ephedrine has any effect on dexmedetomidine-induced antinociception and locomotor inhibitor act.....