Vol. 32 (1) 2011 Neuro endocrinology letters

Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways.

: There is now evidence that depression, as characterized by melancholic symptoms, anxiety, and fatigue and somatic (F&S) symptoms, is the clinical expression of peripheral cell-mediated activation, inflammation and induction of oxidative and nitrosative stress (IO&NS) pathways and of central microglial activation, decreased neurogenesi.....