Vol. 30 (2) 2009 Neuro endocrinology letters

Synergistic interaction between rilmenidine and ibuprofen in the writhing test in mice.

OBJECTIVES: The aim of the study was to ascertain whether rilmenidine, a second generation imidazoline-alpha-2-adrenoreceptor agonist, is able to increase analgesic effects of ibuprofen in the writhing test in mice. Experimental studies combining these agents have not yet been published.

METHODS: An acetic acid (.....