Vol. 29 (4) 2008 Neuro endocrinology letters

Effect of selenium compound (selol) on the opioid activity in vincristine induced hyperalgesia.

PURPOSE: Effect of organoselenium compound (selol), on antinociceptive action of opioid agonists in vincristine neuropathic pain model was investigated.

METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitt.....