CTLA-4 gene polymorphisms predispose to autoimmune endocrinopathies but not to celiac disease.
OBJECTIVES: The aim of the study was to determine the association of two CTLA-4 gene polymorphisms (CT60, +49 A/G) with Hashimoto thyroiditis (HT), type 1 diabetes mellitus (T1DM) and celiac disease (CD) as well as with the occurrence of multi-organ involvement by autoimmunity in children.
METHODS: Genotyping was.....