Vol. 26 (6) 2005 Neuro endocrinology letters

Effects of different antioxidants on lipid peroxidation in brain homogenates, induced by L-thyroxine administration in rats.

OBJECTIVE: It is known that thyrotoxicosis induces lipid peroxidation (LPO). In contrast, propylthiouracil (PTU), a thyrostatic drug is a well-known antioxidant. Also melatonin has been shown to protect against free radical-induced neuronal destruction. At the same time, it is generally accepted that the brain is the most vulnerable tis.....