Vol. 26 (4) 2005 Neuro endocrinology letters

Different signaling in pig anterior pituitary cells by GnRH and its complexes with copper and nickel.

: Gonadotropin releasing hormone (GnRH) is an essential factor in the regulation of synthesis and release of pituitary gonadotropins. After binding to specific receptors and coupling with G proteins, it triggers the intracellular signaling involving the synthesis of inositol phosphates and diacylglycerol. Previously we have showed that .....