Vol. 23 (4) 2002 Neuro endocrinology letters

Dehydroepiandrosterone regulation of prolactin gene expression in the anterior pituitary does not depend on galanin induction.

OBJECTIVES: The effects of dehydroepiandrosterone (DHEA) on galanin (GAL) and prolactin (PRL) mRNA expression in the anterior pituitary of Fischer 344 rats were studied, taking in consideration that: (1) DHEA is an androgen with estrogenic activity on pituitary lactotrophs; (2) estrogens induce prolactinomas in Fischer 344 rats; and (3).....