Vol. 26 (6) 2005 Neuro endocrinology letters

Testosterone levels and histological features of reproductive glands in adult male rats treated neonatally with tamoxifen.

OBJECTIVE: In this study we examined the possibility that demasculinization produced by the neonatal administration of tamoxifen is accompanied by a decline in plasma levels of testosterone during adulthood.

METHODS: Wistar male rats received either a treatment with 12.5 microg/kg of tamoxifen during the first ei.....