The role of selected immunoregulatory cell populations in autoimmune demyelination.

: Much experimental and clinical evidence has been accumulated indicating the complexity of regulatory processes associated with autoimmune demyelination. Even slight disbalance of immunoregulatory circuits may result in the loss of proper control of self antigen specific immune reaction. Here, we discuss the immunoregulatory potential of several immune (dendritic cells and regulatory T cells), as well as non-immune cell populations (mesenchymal stem cells and astrocytes) with regard to their possible role in autoimmune demyelination.

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