Vol. 37 (3) 2016 Neuro endocrinology letters

Pomegranate and licorice juices modulate metformin pharmacokinetics in rats.

OBJECTIVES: Food or drinks may significantly alter the pharmacokinetics and pharmacodynamics of drugs which may lead to adverse events. A drug such as metformin is widely used to regulate plasma glucose level and pomegranate and licorice have been identified to help in type-2 diabetes management. However, the interactions of the latter .....