Vol. 30 (Suppl 1) 2009 Neuro endocrinology letters

Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells.

OBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action with promising brain tumor specificity. This anticancer agent should be considered a pro-drug, whose pharmacological efficiency and/or genotoxic side effects are dependent on its cytochrome P450 (CYP) - and/or peroxidase-mediated activation.....