Sulc M, Mrizova I, Cerna T, Frei E, Eckschlager T, Adam V, Kopeckova K, Stiborova M.
Journal Article 2016; 37(Suppl 1): 95-102 PubMed PMID: 28263536 Keywords: Antineoplastic Agents, Phytogenic:metabolism, Cytochrome P-450 CYP3A:metabolism, DNA Adducts:metabolism, Ellipticines:metabolism, Humans, Liposomes, Microsomes,. CitationOBJECTIVES: Ellipticine is an anticancer agent that functions through multiple mechanisms participating in cell cycle arrest and .....
Sulc M, Mrizova I, Cerna T, Frei E, Eckschlager T, Adam V, Kopeckova K, Stiborova M. Effectiveness of human cytochrome P450 3A4 present in liposomal and microsomal nanoparticles in formation of covalent DNA adducts by ellipticine. Neuro Endocrinol Lett. 2016 Dec; 37(Suppl 1): 95-102
Stiborova M, Manhartova Z, Hodek P, Adam V, Kizek R, Eckschlager T, Frei E.
Journal Article 2015; 36(Suppl 1): 22-28 PubMed PMID: 26757112 Keywords: Animals, Antineoplastic Agents:pharmacology, Cell Survival:drug effects, DNA Adducts:drug effects, Ellipticines:pharmacology, HL-60 Cells, Humans, In Vitro Techniques, Liver:drug effects, Micelles, Rats,. CitationOBJECTIVES: The improvements of cancer treatment are the major challenge in oncology research. Nanocarriers are one of the promising appro.....
Stiborova M, Manhartova Z, Hodek P, Adam V, Kizek R, Eckschlager T, Frei E. Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 1): 22-28
Indra R, Moserova M, Kroftova N, Sulc M, Martinkova M, Adam V, Eckschlager T, Kizek R, Arlt V, Stiborova M.
Journal Article 2014; 35(Suppl 2): 105-113 PubMed PMID: 25638374 Keywords: Benzo(a)pyrene:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:metabolism, Humans, NADH, NADPH Oxidoreductases:metabolism,. CitationOBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activ.....
Indra R, Moserova M, Kroftova N, Sulc M, Martinkova M, Adam V, Eckschlager T, Kizek R, Arlt V, Stiborova M. Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5. Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 2): 105-113
Bednarova I, Mikulaskova H, Havelkova B, Strakova L, Beklova M, Sochor J, Hynek D, Adam V, Kizek R.
Journal Article 2014; 35(Suppl 2): 35-42 PubMed PMID: 25638364 Keywords: Environmental Monitoring, Palladium:toxicity, Plants:anatomy & histology, Platinum Compounds:toxicity, Rhodium:toxicity, Water Pollution, Chemical:adverse effects,. CitationOBJECTIVES: Road traffic pollutants and the residues of cytostatics that are widely used in anti-cancer therapy are a significant.....
Bednarova I, Mikulaskova H, Havelkova B, Strakova L, Beklova M, Sochor J, Hynek D, Adam V, Kizek R. Study of the influence of platinum, palladium and rhodium on duckweed (Lemna minor). Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 2): 35-42
Heger Z, Zitka O, Krizkova S, Beklova M, Kizek R, Adam V.
Journal Article 2013; 34(Suppl 2): 123-129 PubMed PMID: 24362104 Keywords: Animals, Cell Proliferation:drug effects, Estradiol:metabolism, Gene Expression Regulation:drug effects, Humans, Male, Protein Binding:drug effects, Receptors, Estrogen:metabolism, Response Elements:drug effects,. Citation: Group of estrogen pollutants, where the highest estrogen activity is reported at estradiol, is characterized by the fact that even at ve.....
Heger Z, Zitka O, Krizkova S, Beklova M, Kizek R, Adam V. Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 123-129
Kovarova J, Celechovska O, Kizek R, Adam V, Harustiakova D, Svobodova Z.
Journal Article 2009; 30(Suppl 1): 169-176 PubMed PMID: 20027166 Keywords: Animals, Biomarkers:analysis, Cadmium:analysis, Cyprinidae:metabolism, Cysteine:metabolism, Czech Republic, Glutathione:metabolism, Liver:chemistry, Metals:analysis, Rivers:chemistry, Spectrophotometry, Atomic, Sulfhydryl Compounds:analysis,. CitationOBJECTIVES: The aim of this study was to assess the effect of metals, with special attention of cadmium (Cd), content of the Svitava and S.....
Kovarova J, Celechovska O, Kizek R, Adam V, Harustiakova D, Svobodova Z. Effect of metals, with special attention of Cd, content of the Svitava and Svratka rivers on levels of thiol compounds in fish liver and their use as biochemical markers. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 169-176