Vol. 28 (3) 2007 Neuro endocrinology letters

Rearrangements of NTRK1 oncogene in papillary thyroid carcinoma.

: Papillary thyroid carcinoma (PTC) represents an example of tumour with high incidence of oncogenic sequences, such as RET/PTC and Trk. Both of them arise from the fusion of 3' terminal sequences of TK domain of RET or NTRK1 gene, respectively, with 5' terminal sequences of their activating genes. In case of NTRK1 oncogene, several rea.....