Vitamin E supplementation in phenytoin induced developmental toxicity in rats: postnatal study.
OBJECTIVES: The aim of this study was to test the effect of supranutritional dosage of the natural antioxidant vitamin E (VitE) on phenytoin (PHT) induced developmental toxicity and possible long-term effects in rat offspring.
METHODS: PHT (150 mg/kg) was administered by oral gavage daily from day 7 to 18 of gest.....