Vol. 24 (6) 2003 Neuro endocrinology letters

Tracking the elusive antiestrogenic effect of melatonin: a new methodological approach.

OBJECTIVES: Detection of the antiestrogenic effect of melatonin on various breast cancer cell lines and its dependence of the differential expression of estrogen receptors (ERalpha and ERbeta) and melatonin receptors (mt1 and RZRalpha).

SETTING AND DESIGN: Dose-response curves of estradiol were determined in 6 di.....