Vol. 24 (6) 2003 Neuro endocrinology letters

In humans, corticotropin releasing hormone antagonizes some of the negative immunoregulatory effects of serotonin.

: Both corticotropin releasing hormone (CRH) and serotonin (5-HT) participate in the stress response and are known to modulate cytokine release by human immune cells. Extracellular 5-HT concentrations at or above the serum values have negative immunoregulatory effects by inhibiting the production of interferon-gamma (IFNgamma), a pro-in.....