Association between body mass index and insulin receptor substrate-4 (IRS-4) gene polymorphisms in patients with schizophrenia.
OBJECTIVES: The insulin receptor substrate-4 (IRS-4) protein is highly expressed in the hypothalamus that plays a main role in the regulation of body weight. Therefore, as overweight and obesity are more frequent in patients with schizophrenia compared to the general population, this study was undertaken to investigate potential associa.....