Vol. 30 (Suppl 1) 2009 Neuro endocrinology letters

The effect of different molecular weight hyaluronan on macrophage physiology.

OBJECTIVES: Hyaluronan, a linear glycosaminoglycan, is an abundant component of extracellular matrix. In its native form, the high-molar-mass hyaluronan polymers have an array of structural and regulatory, mainly anti-inflammatory and anti-angiogenic, functions. In contradiction, the biological effects of fragmented low molecular weight.....