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NEUROENDOCRINOLOGY
LETTERS
including
Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X
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NEL
Vol.24 Nos.3/4, Jun-Aug 2003
REVIEW
ARTICLE
Etiopathogenesis
of Graves’ disease
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2003;
24:161–166
pii: NEL243403R03
PMID: 14523350
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REVIEW
ARTICLE
Etiopathogenesis
of Graves’ disease
Michal
Karasek & Andrzej Lewinski
1. Department of Endocrinology and Isotope Therapy, Medical
University of Lodz – Polish Mother’s Memorial Hospital – Research
Institute, Lodz, Poland.
2. Department of Electron Microscopy, Chair of Pathomorphology,
Medical University of Lodz, Poland.
Submitted:
December 18, 2002
Accepted: February 24, 200
Key
words:
Graves’ disease, autoimmune diseases, hyperthyroidism,
ophtalmopathy, dermopathy
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Abstract
Graves’
disease is an autoimmune disorder, caused by thyroid-stimulating
antibodies, which bind to and activate the thyrotropin receptor
on thyroid cells, inducing the synthesis and release of thyroid
hormones. It is a polygenic and multifactorial disease that
develops as a result of complex interaction between genetic
susceptibility and environmental and/or endogenous factors.
Graves’ disease differs from other autoimmune diseases
of the thyroid by specific clinical features, including hyperthyroidism,
vascular goitre, ophthalmopathy and - less commonly –
infiltrative dermopathy. This article discusses current theories,
regarding the etiology and pathogenesis of Graves’ disease,
including possible predisposing factors, autoimmune aspects
of Graves’ disease, ophthalmopathy, and dermopathy.
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__________________________________________________________
Copyright © Neuroendocrinology Letters 2003
Society of Integrated Sciences
All rights reserved. No part may be reproduced, stored in a
retrieval system, or transmitted in any form or by any means,
electronic, mechanical, photocopying, recording, or ortherwise,
without prior written permission from the Editor-in-Chief.
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