Vol. 24 (3-4) 2003 Neuro endocrinology letters

Effects of central and peripheral administration of leptin on pain threshold in rats and mice.

OBJECTIVE: This study was planned to investigate the effects of exogenous leptin on the pain threshold.

METHODS: Adult male Wistar rats weighing 250-300 g and mice weighing 25-30 g were used in this study. Leptin was intracerebroventricularly (i. c. v.) injected in a dose of 3.5 micro g/rat. Mice were intraperito.....