Effects of central and peripheral administration of leptin on pain threshold in rats and mice.
OBJECTIVE: This study was planned to investigate the effects of exogenous leptin on the pain threshold.
METHODS: Adult male Wistar rats weighing 250-300 g and mice weighing 25-30 g were used in this study. Leptin was intracerebroventricularly (i. c. v.) injected in a dose of 3.5 micro g/rat. Mice were intraperito.....