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Articles by author - Marie Stiborova

Induction of cytochromes P450 in small intestine by chemopreventive compounds.

Krizkova J, Burdova K, Hudecek J, Stiborova M, Hodek P.

Journal Article 2008; 29(5): 717-721 PubMed PMID: 18987596  Keywords:  Allyl Compounds:pharmacology, Animals, Anticarcinogenic Agents:pharmacology, Blotting, Western, Curcumin:pharmacology, Cytochrome P-450 CYP1A1:biosynthesis, Cytochrome P-450 CYP2B1:biosynthesis, Cytochrome P-450 Enzyme System:biosynthesis, Flavonoids:phar.    Citation

OBJECTIVES: Since flavonoids and other natural compounds exert beneficial effects on human health, their consumption rapidly increases. Ho.....

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Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA.

Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M.

Journal Article 2008; 29(5): 728-732 PubMed PMID: 18987592  Keywords:  Acetyl Coenzyme A:metabolism, Arylamine N-Acetyltransferase:metabolism, Arylsulfotransferase:metabolism, Autoradiography, Catalysis, DNA:chemistry, DNA Adducts:chemistry, Deoxyguanosine:chemistry, Ellipticines:chemistry, Hydrogen-Ion Concentration, Indica.    Citation

OBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of its action. Recently, we have found that 13-hyd.....

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Structural analysis of binding of a diamantoid substrate to cytochrome P450 2B4: possible role of Arg 133 in modulation of function and activity of this enzyme.

Sulc M, Hudecek J, Stiborova M, Hodek P.

Journal Article 2008; 29(5): 722-727 PubMed PMID: 18987581  Keywords:  Adamantane:analogs & derivatives, Amino Acid Sequence, Animals, Arginine:genetics, Aryl Hydrocarbon Hydroxylases:antagonists & inhibitors, Chromatography, High Pressure Liquid, Crystallography, X-Ray, Cytochrome P450 Family 2, Enzyme Inhibitors:pharmacolo.    Citation

OBJECTIVES: Understanding the enzyme mechanism of P450 enzymes needs a detailed knowledge of substrate-enzyme interactions. Here, we exami.....

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Modulation of CYP1A1-mediated oxidation of carcinogenic azo dye Sudan I and its binding to DNA by cytochrome b5.

Stiborová M, Martínek V, Schmeiser H, Frei E.

Journal Article 2006; 27(Suppl 2): 35-39 PubMed PMID: 17159775  Keywords:  Animals, Coloring Agents:pharmacokinetics, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:physiology, DNA:metabolism, DNA Adducts:metabolism, Humans, Male, Metabolic Detoxication, Phase I, Models, Biological, Naphthols:metabolism, Rabbits, Rats, Rats,.    Citation

OBJECTIVES: Modulation of the cytochrome P450 (CYP) 1A1-mediated oxidative activation and detoxication of carcinogenic Sudan I by the heme.....

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Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes.

Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M.

Evaluation Studies 2006; 27(Suppl 2): 18-22 PubMed PMID: 17159771  Keywords:  Animals, Antineoplastic Agents:pharmacokinetics, Cytochrome P-450 Enzyme System:chemistry, DNA Adducts:metabolism, Ellipticines:pharmacokinetics, Metabolic Detoxication, Phase I, Microsomes, Liver:chemistry, Models, Biological, NADP:chemistry, NADPH-Ferri.    Citation

OBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple action mechanisms. Recently, we found that after cytochrome P.....

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Toxicological aspects of flavonoid interaction with biomacromolecules.

Hodek P, Hanustiak P, Krízková J, Mikelova R, Krízková S, Stiborová M, Trnková L, Horna A, Beklová M, Kizek R.

Journal Article 2006; 27(Suppl 2): 14-17 PubMed PMID: 17159770  Keywords:  Adenine:metabolism, Animals, Colon:drug effects, Cytochrome P-450 CYP1A1:metabolism, DNA, Single-Stranded:metabolism, Electrochemistry, Enzyme Activation:drug effects, Flavonoids:metabolism, Guanidine:metabolism, Male, Microsomes, Liver:drug effects, Mode.    Citation

OBJECTIVES: Flavonoids are widely accepted as health promoting phytochemicals, however, some flavonoids show ability of direct interaction.....

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