OBJECTIVE: To investigate the relationship between sex hormone-binding globulin (SHBG) and blood glucose in elder men of Uygur ethnic group. METHODS: A total of 467 males of ugyur ethnic group resident in Urumqi, Tuokesun County, and Turpan were included by cluster sampling, classified by ages and SHBG level, and compared the metabolic index to define the risk factors by regression. RESULTS: BMI, waist circumference (WC), glycosylated hemoglobin (GH), fasting insulin level (FIL), SHBG, testosterone, free testosteroneindex (FAI), and HOMA-IR were statistically different in different age groups (P<0.05); the differences in the age, BMI, WC, fasting blood glucose (FBG), OGTT 2-hr blood glucose, HOMA-IR, FIL, GH, testosterone, and F among the study subjects grouped according to SHBG level were statistically significant (P<0.05); the logistic regression analysis revealed that FIL and testosterone were the independent factors that will affect SHBG in the models using FIL, HOMA-IR, and other indexes with statistical significance as the continuous variables and the interquartile grouping of SHBG as the independent variables. CONCLUSIONS: Among middle-aged and elder males, there are differences in the sex hormone and SHBG levels. The independent influencing factors of SHBG are HOMA-IR, testosterone, and FIL.