Articles by author - Miroslav Pohanka

7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid.

Starka L, Hill M, Kancheva R, Novak Z, Chrastina J, Pohanka M, Morfin R.

Journal Article 2009; 30(3): 368-372 PubMed PMID: 19855361  Keywords:  Adult, Androstenols:blood, Dehydroepiandrosterone:analogs & derivatives, Female, Humans, Hydrocephalus:blood, Male, Mass Spectrometry,.    Citation

OBJECTIVE: Dehydroepiandrosterone is a long established neuroactive steroid. Some authors documented that 7-oxygenated derivatives of this.....

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New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine.

Pohanka M, Kuca K, Kassa J.

Comparative Study 2008; 29(5): 755-758 PubMed PMID: 18987590  Keywords:  Acetylcholinesterase:chemistry, Algorithms, Alzheimer Disease:drug therapy, Biosensing Techniques, Cholinesterase Inhibitors:analysis, Electrochemistry, Enzymes, Immobilized:chemistry, Humans, Kinetics, Nootropic Agents:analysis, Tacrine:analogs & derivat.    Citation

: Two drugs were tested using electrochemical biosensor with immobilized acetylcholinesterase (AChE). The first was commercialized drug ta.....

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The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder.

Soukup O, Pohanka M, Tobin G, Jun D, Fusek J, Musilek K, Marek J, Kassa J, Kuca K.

Journal Article 2008; 29(5): 759-762 PubMed PMID: 18987577  Keywords:  Acetylcholinesterase:metabolism, Animals, Biosensing Techniques, Butyrylcholinesterase:metabolism, Cholinesterase Inhibitors:pharmacology, Methacholine Chloride:pharmacology, Muscarinic Agonists:pharmacology, Oximes, Parasympathetic Nervous System:drug ef.    Citation

OBJECTIVES: The current standard treatment of organophosphate poisoning consists of an administration of anticholinergic drugs and choline.....

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