Articles by author - Kamil Musilek

HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs.

Kuneš M, Květina J, Bureš J, Karasová J, Pavlík M, Tachecí I, Musílek K, Kuca K.

Journal Article 2014; 35(Suppl 2): 191-196 PubMed PMID: 25638385  Keywords:  Animals, Cholinesterase Reactivators:administration & dosage, Female, Oximes:administration & dosage, Pyridinium Compounds:administration & dosage, Sus scrofa:blood, Tissue Distribution,.    Citation

OBJECTIVES: Oxime HI-6 DMS (dimethanesulfonate) is an asymmetric bis-pyridinium aldoxime and essential acetylcholinesterase (AChE.....

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The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder.

Soukup O, Pohanka M, Tobin G, Jun D, Fusek J, Musilek K, Marek J, Kassa J, Kuca K.

Journal Article 2008; 29(5): 759-762 PubMed PMID: 18987577  Keywords:  Acetylcholinesterase:metabolism, Animals, Biosensing Techniques, Butyrylcholinesterase:metabolism, Cholinesterase Inhibitors:pharmacology, Methacholine Chloride:pharmacology, Muscarinic Agonists:pharmacology, Oximes, Parasympathetic Nervous System:drug ef.    Citation

OBJECTIVES: The current standard treatment of organophosphate poisoning consists of an administration of anticholinergic drugs and choline.....

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