Poljakova J, Hrebackova J, Dvorakova M, Moserova M, Eckschlager T, Hrabeta J, Göttlicherova M, Kopejtkova B, Frei E, Kizek R, Stiborova M.
Journal Article 2011; 32(Suppl 1): 101-116 PubMed PMID: 22167207 Keywords: Animals, Antineoplastic Combined Chemotherapy Protocols:pharmacology, Brain Neoplasms:drug therapy, DNA Damage, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Ellipticines:administration & dosage, Histone Deacetylase Inhibitors:administra. CitationOBJECTIVES: Valproic acid (VPA) and trichostatin A (TSA) exert antitumor activity as histone deacetylase inhibitors, whereas ellipticine a.....
Poljakova J, Hrebackova J, Dvorakova M, Moserova M, Eckschlager T, Hrabeta J, Göttlicherova M, Kopejtkova B, Frei E, Kizek R, Stiborova M. Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 101-116
Stiborova M, Moserova M, Mrazova B, Kotrbova V, Frei E.
Journal Article 2010; 31(Suppl 2): 26-35 PubMed PMID: 21187821 Keywords: Animals, Antineoplastic Agents:metabolism, Biotransformation:drug effects, Cytochrome P-450 Enzyme System:physiology, DNA Adducts:drug effects, Ellipticines:metabolism, Kidney:metabolism, Liver:metabolism, Lung:metabolism, Male, Microsomes:drug effects, M. CitationOBJECTIVE: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action. This anticancer agent should be consider.....
Stiborova M, Moserova M, Mrazova B, Kotrbova V, Frei E. Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney. Neuro Endocrinol Lett. 2010 Jan; 31(Suppl 2): 26-35
Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M.
Journal Article 2008; 29(5): 728-732 PubMed PMID: 18987592 Keywords: Acetyl Coenzyme A:metabolism, Arylamine N-Acetyltransferase:metabolism, Arylsulfotransferase:metabolism, Autoradiography, Catalysis, DNA:chemistry, DNA Adducts:chemistry, Deoxyguanosine:chemistry, Ellipticines:chemistry, Hydrogen-Ion Concentration, Indica. CitationOBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of its action. Recently, we have found that 13-hyd.....
Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M. Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA. Neuro Endocrinol Lett. 2008 Oct; 29(5): 728-732