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Neuroinfections due to Staphylococcus aureus: an emerging pathogen also in community acquired meningitis.

Benca J, Lesnakova A, Holeckova K, Ondrusova A, Wiczmandyova O, Sladeckova V, Hvizdak F, Bartkovjak M, Seckova S, Taziarova M, Huttova M, Bielova M, Luzica R, Karvaj M, Kovac M, Bauer F, Sabo I, Svabova V, Findova L, Bukovinova P, Shahum A.
Journal Article 2007; 28(Suppl 3): 33-34 PubMed PMID: 18030276 Citation  Keywords:  Anti-Bacterial Agents:therapeutic use, Community-Acquired Infections:drug therapy, Diabetes Complications:drug therapy, Diabetes Mellitus, Humans, Meningitis, Bacterial:drug therapy, Outcome Assessment (Health Care), Oxacillin:therapeutic use, Staphylococ.   

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An experimental Staphylococcus aureus meningitis model for investigating induced leptomeningeal and subpial inflammation in rats: a transmission electron microscopy study.

Guzel A, Er U, Tatli M, Aluclu M, Ozekinci T, Nergiz Y, Ahishali B, Aktas G, Kavak V, Nergiz S, Ozkan U, Satici O.
Journal Article 2007; 28(5): 652-658 PubMed PMID: 17984956 Citation  Keywords:  Animals, Arachnoid:microbiology, Brain:microbiology, Disease Models, Animal, Meninges:microbiology, Meningitis, Bacterial:microbiology, Pia Mater:microbiology, Random Allocation, Rats, Rats, Sprague-Dawley, Spinal Cord:microbiology, Staphylococcus aureus:.   

OBJECTIVE: To evaluate leptomeningeal and subpial inflammatory responses of experimental Staphylococcus aureus bacteriemia following intraperitoneal and intravenous applications and to compare the inflammatory reactions in different regions of central nervous system.

MATERIAL AND METHODS: Forty anesthetized rats were divided into four groups equal in number. The rats in group-I were given 1 ml suspension of Staphylococcus aureus intraperitoneally. Group-II was the control group of group I; it was administrated 1 ml 0.9% NaCl in water intraperitoneally. The rats in group-III were given the same amount of bacteria intravenously. Group IV was the control group of the group-III; it was administrated 1 ml 0.9% NaCl solution intravenously. The rats were sacrificed on the 21st day. Inflammatory changes of different regions of the central nervous system were examined under transmission electron microscopy. Statistical analysis was done by using variance analysis, Bonferroni, Tamhane post hoc, Student's t and univariate tests.

RESULTS: Thoracic and occipital regions were the most vulnerable zones. Increasing of collagen tissue was the most detected inflammatory change.

CONCLUSION: This experimental model can be used for inducing subpial and leptomeningeal inflammations and it may be developed for investigations of pathogenesis of leptomeningitis during systemic infections....

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National 14 years survey of 171 cases nosocomial meningitis in children and comparison of two periods 1993-1998 to 1999-2006.

Rudinsky B, Ondrusova A, Kisac P, Sramka M, Beno P, Miklosko J, Freybergh P, Bauer F, Huttova M.
Comparative Study 2007; 28(Suppl 2): 11-14 PubMed PMID: 17558366 Citation  Keywords:  Child, Child, Preschool, Cross Infection:epidemiology, Data Collection, Gram-Negative Bacterial Infections:epidemiology, Humans, Infant, Infant, Newborn, Meningitis, Bacterial:epidemiology, Risk Factors, Slovakia:epidemiology, Staphylococcal Infections:ep.   

: In 1993-1998 and in 1999-2004 we have performed two surveys of pediatric bacterial meningitis in all 8 neurosurgery/pediatrics and infectious diseases departments in Slovakia. We have detected 101 and another 54 cases with attributable mortality of 15% and sequellae in 18%....

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