Aluminum-induced neurotoxicity and oxidative damage in rabbits: protective effect of melatonin.

Journal Article 2005; 26(5): 609-616 PubMed PMID: 16264393 Keywords: Aluminum:antagonists & inhibitors, Animals, Antioxidants:therapeutic use, Apoptosis:drug effects, Brain:metabolism, Lipid Peroxidation:drug effects, Male, Malondialdehyde:metabolism, Melatonin:therapeutic use, Nerve Degeneration:pathology, Neurofibrils:pa.

OBJECTIVE: The present study was aimed to investigate: (1) the neurotoxic oxidative damage of orally administered aluminum chloride (AlCl3.....

Melatonin supplementation restores cellular proliferation and DNA synthesis in the splenic and thymic lymphocytes of old rats.

Journal Article 2003; 24(3-4): 215-223 PubMed PMID: 14523360 Keywords: Aging:metabolism, Animals, Autoradiography, Cell Division:drug effects, DNA:biosynthesis, Male, Melatonin:pharmacology, Microscopy, Electron, Rats, Rats, Sprague-Dawley, Spleen:cytology, T-Lymphocytes:drug effects, Thymus Gland:drug effects,.

OBJECTIVES: In this study we investigated the effect of melatonin treatment on the proliferative activity, the rate of DNA synthesis and t.....

Journal Article 2002; 23(4): 335-340 PubMed PMID: 12195237 Keywords: Animals, Anticonvulsants:pharmacology, Cell Division:drug effects, DNA:biosynthesis, Drug Interactions, Hepatocytes:drug effects, Male, Melatonin:pharmacology, Mutagens:pharmacology, Necrosis, Nitroparaffins:pharmacology, Propane:analogs & derivatives, Ra.

OBJECTIVES: 2-Nitropropane (2-NP) is mutagenic in a number of short-term mutagenicity assays in vitro and in vivo, and is a potent hepatoc.....

Journal Article 2001; 22(2): 93-99 PubMed PMID: 11335885 Keywords: Alcoholism:complications, Animals, Autoradiography, Cell Division:drug effects, Ethanol:administration & dosage, Leydig Cells:drug effects, Male, Rats, Rats, Sprague-Dawley, Seminiferous Tubules:drug effects, Spermatogonia:drug effects, Testicular Disease.

OBJECTIVES: Considering the possibility that alcoholism induces gonadal dysfunction, the present work was designed to investigate the morp.....

Journal Article 2000; 21(6): 461-468 PubMed PMID: 11335867

: OBJECTIVES: Free radical scavengers can protect against the genotoxicity induced by chemical carcinogens by decreasing oxidative stress......