Borek-Dohalska L, Klusonova Z, Holecova J, Martinkova M, Barta F, Dracinska H, Cajthaml T, Stiborova M.
Journal Article 2016; 37(Suppl 1): 84-94 PubMed PMID: 28263535 Keywords: Animals, Benzo(a)pyrene:pharmacology, Cytochrome P-450 Enzyme System:metabolism, Endocrine Disruptors:pharmacology, Estradiol:pharmacology, Estrogens:pharmacology, Ethinyl Estradiol:pharmacology, Male, Microsomes, Liver:metabolism, Rats, Rats, Wistar,. CitationOBJECTIVES: The term "endocrine disruptor" (ED) is used for compounds that mimic or antagonize the effects of endogenous hormones. Synthet.....
Borek-Dohalska L, Klusonova Z, Holecova J, Martinkova M, Barta F, Dracinska H, Cajthaml T, Stiborova M. Exposure of rats to exogenous endocrine disruptors 17alpha-ethinylestradiol and benzo(a)pyrene and an estrogenic hormone estradiol induces expression of cytochromes P450 involved in their metabolism. Neuro Endocrinol Lett. 2016 Dec; 37(Suppl 1): 84-94
Stiborova M, Levova K, Barta F, Dracinska H, Sulc M, Hodek P, Frei E, Arlt V, Schmeiser H.
Journal Article 2014; 35(Suppl 2): 123-132 PubMed PMID: 25638376 Keywords: Animals, Aristolochic Acids:metabolism, Dicumarol:pharmacology, Enzyme Inhibitors:pharmacology, Humans, Quinone Reductases:metabolism, Rats,. CitationOBJECTIVES: Dicoumarol is known to act as an inhibitor of
NAD(P)H: quinone oxidoreductase (NQO1). T.....
Stiborova M, Levova K, Barta F, Dracinska H, Sulc M, Hodek P, Frei E, Arlt V, Schmeiser H. Dicoumarol inhibits rat NAD(P)H:quinone oxidoreductase in vitro and induces its expression in vivo. Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 2): 123-132
Mizerovska J, Dracinska H, Arlt V, Schmeiser H, Frei E, Stiborova M.
Journal Article 2009; 30(Suppl 1): 52-59 PubMed PMID: 20027145 Keywords: Animals, Benz(a)Anthracenes:metabolism, Chromatography, High Pressure Liquid:methods, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System:metabolism, Humans, Inhibitory Concentration 50, Kinetics, Male, Microsomes, Liver:enzymology, Oxidati. CitationOBJECTIVES: 3-Aminobenzanthrone (3-ABA) is the main human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone (3-NBA). .....
Mizerovska J, Dracinska H, Arlt V, Schmeiser H, Frei E, Stiborova M. Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 - similarity between human and rat enzymes. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 52-59
Svobodova M, Martinkova M, Dracinska H, Frei E, Stiborova M.
Journal Article 2009; 30(Suppl 1): 46-51 PubMed PMID: 20027144 Keywords: Animals, Anisoles:metabolism, Chromatography, High Pressure Liquid:methods, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System:metabolism, Humans, Inhibitory Concentration 50, Kinetics, Microsomes, Liver:enzymology, Nitrophenols:metabolism. CitationOBJECTIVES: 2-Nitrophenol (2-NP) is the major detoxification metabolite of an important industrial pollutant and a potent carcinogen, 2-ni.....
Svobodova M, Martinkova M, Dracinska H, Frei E, Stiborova M. Rat cytochromes P450 oxidize 2-nitrophenol, a human metabolite of carcinogenic 2-nitroanisole. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 46-51
Dracínska H, Miksanová M, Svobodová M, Smrcek S, Frei E, Schmeiser H, Stiborová M.
Journal Article 2006; 27(Suppl 2): 9-13 PubMed PMID: 17159769 Keywords: Adolescent, Adult, Aged, Aniline Compounds:metabolism, Animals, Anisoles:pharmacokinetics, Carcinogens:pharmacokinetics, Child, Child, Preschool, Cytochrome P-450 Enzyme System:metabolism, Female, Humans, In Vitro Techniques, Male, Metabolic Detoxication,. CitationOBJECTIVES: The detoxifying metabolism of a potent rodent carcinogen, 2-nitroanisole (2-NA) by human, rabbit and rat cytochromes P450 (P45.....
Dracínska H, Miksanová M, Svobodová M, Smrcek S, Frei E, Schmeiser H, Stiborová M. Oxidative detoxication of carcinogenic 2-nitroanisole by human, rat and rabbit cytochrome P450. Neuro Endocrinol Lett. 2006 Dec; 27(Suppl 2): 9-13