Vol. 31 (2) 2010 Neuro endocrinology letters

The role of oxidative stress and endothelial injury in diabetic neuropathy and neuropathic pain.

OBJECTIVE: The roles of endothelin-1 (ET-1) and oxidative stress causing vascular injury in the pathogenesis of diabetic neuropathy are debatable. The present study was undertaken to clarify the possible effects of oxidative stress and ET-1 in diabetic patients with and without peripheric neuropathy.

METHODS: We .....