Parkin mutations and phenotypic features in Czech patients with early-onset Parkinson's disease.
OBJECTIVES: Mutations in several genes such as parkin can be detected in up to 20% of patients with early-onset Parkinson's disease (EOPD). The aim of our study was to determine the frequency of parkin alterations and phenotypic characteristics in Czech EOPD patients.
METHODS: A total of 45 EOPD individuals (age .....