Effect of the new pyridoindole antioxidant SMe1EC2 on functional deficits and oedema formation in rat hippocampus exposed to ischaemia in vitro.

Gáspárová Z, Janega P, Babál P, Snirc V, Stolc S, Mach M, Ujházy E.

Journal Article 2009; 30(5): 574-581 PubMed PMID: 20035262 Keywords: Animals, Antioxidants:pharmacology, Brain Ischemia:drug therapy, Edema:drug therapy, Electrophysiology, Female, Hippocampus:cytology, Humans, Indoles:pharmacology, Male, Neuroprotective Agents:pharmacology, Pyridines:pharmacology, Rats, Rats, Wistar,.

OBJECTIVES: The idea of neuroprotective therapy for ischaemic stroke is based on results from studies on experimental animal models of brain ischaemia demonstrating efficacy of many natural and synthetic agents. Contrary to positive conclusions with antioxidants from animal models, clinical experience failed to find neuroprotectants so .....

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Vol. 30 (5) 2009 Neuro endocrinology letters

Effect of the new pyridoindole antioxidant SMe1EC2 on functional deficits and oedema formation in rat hippocampus exposed to ischaemia in vitro.

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