Vol. 30 (5) 2009 Neuro endocrinology letters

Acute and chronic effects of antidepressants on the G-protein alpha subunit profiles in vitro and in vivo.

OBJECTIVES: Neurochemical studies on the etiopathogenesis of depression are also focusing on the transduction system beyond receptors. Trimeric G-proteins play a crucial role in the transmembrane signalling, signal amplification and intracellular processing. Abnormalities of G-protein levels are observed in subjects with depression, G-p.....