Vol. 29 (1) 2008 Neuro endocrinology letters

Is there any relation between hyperinsulinemia, insulin resistance and colorectal lesions in patients with acromegaly?

INTRODUCTION: Pathogenesis of colonic lesions in patients with acromegaly remains still unclear. There are suggestions that apart from somatotropin axis hormones (GH and IGF-1), other agents also take part in this process. Molecular and animal studies indicate a vital role of hyperinsulinemia in development of colorectal neoplasms.