Vol. 28 (4) 2007 Neuro endocrinology letters

Assessment of cyclin D1 gene expression as a prognostic factor in benign and malignant thyroid lesions.

OBJECTIVE: Cyclin D1, encoded by CCND1 (cyclin D1) gene with locus in chromosome 11q13, is a protein that plays the key role in the passage through the restriction point in G1 phase of cell cycle. The aim of the study were: 1) an assessment of CCND1 gene expression level in benign and malignant thyroid lesions and 2) the evaluation of p.....