The analgesic effect of pamidronate is not caused by the elevation of beta endorphin level in Paget's disease--a controlled pilot study.

Bender T, Donáth J, Barna I, Gergely P, Poór G.

Controlled Clinical Trial 2006; 27(4): 513-515 PubMed PMID: 16891991 Keywords: Aged, Analgesics:administration & dosage, Bone Density Conservation Agents:administration & dosage, Diphosphonates:administration & dosage, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Osteitis Deformans:complications, Pain:drug therapy, Pai.

INTRODUCTION: Although an analgesic effect is an essential component of the mode of action of bisphosphonates, its physiological mechanisms are still unclear. Beta-endorphin release plays an important role in the analgesic effect of both calcitonin and raloxifene. As patients with Paget's disease receive large doses of bisphosphonates w.....

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Vol. 27 (4) 2006 Neuro endocrinology letters

The analgesic effect of pamidronate is not caused by the elevation of beta endorphin level in Paget's disease--a controlled pilot study.

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