Vol. 24 (3-4) 2003 Neuro endocrinology letters

Evaluation of the pituitary-adrenal axis in hyperandrogenic women with polycystic ovary syndrome.

OBJECTIVES: Impaired adrenal function is common in patients with polycystic ovary syndrome (PCOS). Abnormal regulation of cytochrome P450 17 alpha is believed to cause the exaggerated 17-hydroxyprogesterone (17OHP) response to ACTH stimulation. The aim of the study was to evaluate cortisol and 17OHP response to low dose (1 microg) ACTH .....