Vol. 23 (Suppl 2) 2002 Neuro endocrinology letters

Light during darkness, melatonin suppression and cancer progression.

: Over the past few years, we have shown that the surge of melatonin in the circulation during darkness represents a potent oncostatic signal to tissue-isolated rat hepatoma 7288CTC, which is an ER+ adenocarcinoma of the liver. This oncostatic effect occurs via a melatonin receptor-mediated suppression of tumor cAMP production that lead.....