Vol. 23 (5-6) 2002 Neuro endocrinology letters

Mechanism of ghrelin-evoked glucagon secretion from the pancreas of diabetic rats.

OBJECTIVE: Ghrelin is a newly discovered peptide, which was first demonstrated in the epithelium of rat stomach. The purpose of the study was to examine the effect of ghrelin on glucagon secretion from pancreatic tissue fragments of normal and diabetic rats.

METHODS: Diabetes was induced by streptozotocin (60 mg .....