Articles by author - Michaela Moserova

Role of dihydromyricetin in cytochrome P450-mediated metabolism and carcinogen activation.

Bostikova Z, Moserova M, Pavek P, Stiborova M, Hodek P.

Journal Article 2015; 36(Suppl 1): 46-52 PubMed PMID: 26757127  Keywords:  Animals, Carcinogens:metabolism, Cytochrome P-450 Enzyme System:drug effects, Flavonols:pharmacology, Inhibitory Concentration 50, Intestine, Small:drug effects, Liver:drug effects, Male, RNA, Messenger:drug effects, Rats, Rats, Wistar, Real-Time Polymera.    Citation

OBJECTIVES: Dihydromyricetin (DHM) is a flavonoid, which has been shown to antagonize effects of ethanol intoxication. As a potential phar.....

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Effect of dihydromyricetin on benzo[a]pyrene activation in rats.

Hodek P, Fousova P, Brabencova E, Moserova M, Pavek P, Anzenbacherova E, Brotanek J, Hudecek J, Frei E, Stiborova M.

Journal Article 2014; 35(Suppl 2): 158-168 PubMed PMID: 25638381  Keywords:  Animals, Benzo(a)pyrene:administration & dosage, Carcinogens:administration & dosage, DNA Adducts:administration & dosage, Flavonols:administration & dosage, Male, Rats, Rats, Wistar,.    Citation

OBJECTIVES: Flavanol dihydromyricetin (DHM) has been shown to counteract acute ethanol (EtOH) intoxication and reduce excessive E.....

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Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5.

Indra R, Moserova M, Kroftova N, Sulc M, Martinkova M, Adam V, Eckschlager T, Kizek R, Arlt V, Stiborova M.

Journal Article 2014; 35(Suppl 2): 105-113 PubMed PMID: 25638374  Keywords:  Benzo(a)pyrene:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:metabolism, Humans, NADH, NADPH Oxidoreductases:metabolism,.    Citation

OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activ.....

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Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study.

Indra R, Moserova M, Sulc M, Frei E, Stiborova M.

Comparative Study 2013; 34(Suppl 2): 55-63 PubMed PMID: 24362093  Keywords:  Animals, Benzo(a)pyrene:metabolism, Carcinogens:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:pharmacology, Humans, Inactivation, Metabolic, Male, Microsomes, Liver:drug effects, Oxidation-Reduction, Rats,.    Citation

OBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (B.....

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The effect of benzo[a]pyrene on metabolic activation of anticancer drug ellipticine in mice.

Stiborova M, Cerna V, Moserova M, Arlt V, Frei E.

Journal Article 2013; 34(Suppl 2): 43-54 PubMed PMID: 24362092  Keywords:  Animals, Antineoplastic Agents:pharmacokinetics, Benzo(a)pyrene:pharmacology, Biotransformation:drug effects, Cytochrome P-450 CYP1A1:metabolism, Cytochrome P-450 CYP1A2:metabolism, Cytochrome P-450 Enzyme System:metabolism, Drug Evaluation, Preclinical, .    Citation

OBJECTIVES: The aim of this study was to investigate a role of cytochrome P450 (CYP) and peroxidase in ellipticine oxidative activation in.....

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Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes.

Stiborova M, Cechova T, Borek-Dohalska L, Moserova M, Frei E, Schmeiser H, Paca J, Arlt V.

Journal Article 2012; 33(Suppl 3): 8-15 PubMed PMID: 23353838  Keywords:  Aerobiosis:physiology, Air Pollutants:pharmacokinetics, Anaerobiosis:physiology, Animals, Benz(a)Anthracenes:pharmacokinetics, Carcinogens:pharmacokinetics, Cytochrome P-450 Enzyme System:metabolism, Cytochrome-B(5) Reductase:genetics, DNA Adducts:metabol.    Citation

OBJECTIVES: 2-Nitrobenzanthrone (2-NBA) has recently been detected in ambient air particulate matter. Its isomer 3-nitrobenzanthrone (3-NB.....

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