Articles by author - Jan Lochman

Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population.

Hlousková A, Bonczek O, Izakovicová-Hollá L, Lochman J, Soukalová J, Stembírek J, Mísek I, Cernochová P, Krejcí P, Vanek J, Šerý O.

Journal Article 2015; 36(5): 452-457 PubMed PMID: 26707046  Keywords:  Adolescent, Adult, Aged, Anodontia:genetics, Case-Control Studies, Child, Czech Republic, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Mutation, PAX9 Transcription Factor:genetics, Polymorphism.    Citation

OBJECTIVES: Tooth agenesis is one of the most common developmental anomalies in humans. Genetic and environmental factors may be of etiolo.....

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Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia.

Lochman J, Plesník J, Janout V, Povová J, Míšek I, Dvořáková D, Šerý O.

Journal Article 2013; 34(8): 792-797 PubMed PMID: 24522021  Keywords:  Adult, Epigenesis, Genetic:genetics, Genetic Predisposition to Disease:epidemiology, Genotype, Humans, Male, Methylenetetrahydrofolate Reductase (NADPH2):genetics, Middle Aged, Polymorphism, Genetic, Receptors, Adrenergic, alpha-2:genetics, Risk Factors, .    Citation

OBJECTIVES: Increasing evidences support the importance of epigenetic control in schizophrenia pathogenesis. One of the enzymes involved i.....

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The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction.

Šerý O, Šrámková T, Klempová J, Štastný F, Lochman J, Khan N.

Journal Article 2012; 33(5): 499-504 PubMed PMID: 23090267  Keywords:  Adult, Erectile Dysfunction:blood, Follicle Stimulating Hormone:blood, Genetic Predisposition to Disease:genetics, Genotype, Humans, Luteinizing Hormone:blood, Male, Methylenetetrahydrofolate Reductase (NADPH2):genetics, Middle Aged, Polymorphism, Single .    Citation

OBJECTIVES: The methylenetetrahydrofolate reductase (MTHFR) enzyme activity plays an important role in the metabolism of folate within met.....

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A positive fluid balance does not deteriorate tissue metabolism during fluid resuscitation of sepsis.

Koci J, Oberreiter M, Hyspler R, Ticha A, Valis M, Lochman P, Havel E, Ferko A.

Journal Article 2011; 32(3): 345-348 PubMed PMID: 21712791  Keywords:  Animals, Blood Glucose:metabolism, Escherichia coli Infections:pathology, Fluid Therapy, Glycerol:blood, Hypovolemia:therapy, Isotonic Solutions:therapeutic use, Lactic Acid:blood, Microdialysis, Plasma Substitutes:therapeutic use, Pyruvic Acid:blood, Res.    Citation

OBJECTIVE: Hypovolemia has occurs frequently in sepsis. Due to pathologically increased permeability of the capillaries, the fluid leaks t.....

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Polymorphism of DRD2 gene and ADHD.

Serý O, Drtílková I, Theiner P, Pitelová R, Staif R, Znojil V, Lochman J, Didden W.

Journal Article 2006; 27(1-2): 236-240 PubMed PMID: 16648784  Keywords:  Adolescent, Alleles, Attention Deficit Disorder with Hyperactivity:epidemiology, Child, Czech Republic:epidemiology, DNA:genetics, Gene Frequency, Humans, Male, Polymorphism, Genetic, Psychiatric Status Rating Scales, Receptors, Dopamine D2:genetics, Reve.    Citation

OBJECTIVES: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies s.....

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