Vol. 32 (6) 2011 Neuro endocrinology letters

Methylprednisolone reduces axonal impairment in the experimental model of brain oedema.

OBJECTIVES: In our earlier paper we demonstrated that opening of the blood-brain barrier with an osmotic insult induces brain oedema which represents a factor triggering axonal impairment accompanied with myelin disintegration. The aim of the present study was to find whether methylprednisolone can reduce such axonal impairment in our m.....